can you use glp 1 with sglt2 Diabetic Agents, From Metformin to Inhibitors and GLP1 Receptor Agonists: JACC Focus Seminar Metabolic Powerhouses: GLP-1 RAs and

It has a short half-life in blood of 1.5-3 min due to a high clearance but also activates afferent nerve endings directly before entering the blood

Some women with PCOS report improved menstrual regularity on GLP-1 therapy, likely due to weight loss and improved insulin sensitivity rather than direct effects on the ovaries

Doctors need to carefully distinguish gastroparesis from the normal slowing of gastric emptying that GLP-1 receptor agonists cause

Pharmaceutical companies originally built them for type 2 diabetes

Semaglutide can help people lose an average of 18% of their body weight at the highest dose (Wegovy 7.2 mg), and tirzepatide has been associated with an average of 21% at the 15 mg dose of Zepbound